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Title

Identifying NET mutational gene signatures

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Lay summary

Mutations in many different genes can cause neuroendocrine tumours (NETs) to develop. In addition, patients will have multiple different mutated genes within their tumour. This is known as a tumour gene signature. Currently it is not understood whether specific gene signatures are linked with the development of NETS, and if they are how they are linked with clinical problems. In our project we therefore plan to look at the information in the NET GeCIP to see how many different genes are mutated in each patients’ NET. Once we have done this we will compare the information from each patient see if we can identify common patterns, and therefore identify common gene signatures. Once gene signatures have been found we will study the clinical data to see if patients have common clinical problems, for example aggressiveness of tumour, or survival. Overall, we aim to identify common gene signatures in NET patients and link this to clinical problems to help decide which the best treatments for each individual patient may be.

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