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Understanding the epidemiology of somatic evolution in cancer

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Lay summary

Our research investigates why cancers differ between people at the genetic level, and whether these differences are linked to factors like lifestyle, background, or genes passed down through families. We’re starting with lung cancer, but will later expand to other cancer types.

We already know that certain features of tumours – such as the types of genetic mutations they carry – can vary between individuals. Some of these differences seem to relate to things like sex or smoking history. We want to explore whether these patterns are consistent across different groups of people and different cancers. We’re also interested in whether some of these tumour differences are influenced by the DNA people are born with.

To find out, we’ll analyse detailed health and genetic data from people with cancer. First, we’ll examine whether specific tumour features are linked to traits like age, sex, or lifestyle. Next, we’ll look at inherited genetics to see if common variations are associated with those tumour features.

Although this is an early-stage, exploratory project, it could help us better understand how cancer develops and behaves in different people – and ultimately support more personalised approaches to cancer prevention and treatment.

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