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Clinical Significance of Copy Number Alterations in Treatment of NSCLC

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Lay summary

Immunotherapy is a newer type of treatment that helps the immune system fight cancer. While it works well for some patients with lung cancer, it doesn’t help everyone—and it’s hard to predict who will benefit. Certain changes (mutations) in specific genes can sometimes help doctors guess how well a patient will respond. Two of these important genes are located close together in the cell’s DNA, on a part called chromosome 19. Because they’re so close, both genes can be lost at the same time as a tumor develops. We still don’t fully understand how this loss affects different types of lung cancer or how it influences treatment success.

Using patient data from the United States and Canada, we saw a possible link between changes in chromosome 19 and how patients responded to treatment. Now, we are expanding our research to see if the status of chromosome 19 could be used to better predict which lung cancer patients will respond to immunotherapy, using the larger database of Genomics England. Our goal is to learn more about how these DNA changes affect different types of lung cancer and patient outcomes.

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