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Title

Uncovering the role of multi-scale genetic cooperativity

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Lay summary

Much of genetics research has focused on understanding how a given gene or underlying mutation can cause disease. Here, we are interested in exploring the combined role of multiple genes and mutations in diseases. In our first project aim, we want to understand how mutations in our blood cells that accumulate over time affect mutations that cause cancer in other parts of the body. We want to be able to answer questions like, if you have a certain mutation in your blood cells, are you more likely to develop a certain type/subtype of cancer somewhere else in your body? 

In our second aim, we want to examine how germline mutations (which are found everywhere in the body) and somatic mutations (which are only found in some cells) interact to promote various rare diseases and cancers. We will look for these mutation patterns in healthy people, those with cancer, and those with rare diseases so that we can learn more about how multiple genomic variants can work together to influence different disease phenotypes.

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