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Title

Analysis of healthcare resource use and costs for cancer patients undergoing genome sequencing

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Lay summary

Genomic information has the potential to improve diagnosis and inform treatment decisions for patients. However, sequencing is still considered expensive compared to other diagnostic and testing processes. Understanding whether sequencing is an efficient use of NHS resources is critical to enable policymakers to determine whether or not to provide genomic sequencing across the NHS.

In this study, I will analyse the healthcare resource use and costs associated with conducting genome sequencing for cancer patients in the English NHS.  For the analysis I will use routinely collected NHS hospital data (including inpatient and outpatient data) linked to genomic data in the 100,000 Genome Project, to determine the costs of cancer patients’ healthcare resource use associated with undergoing genome sequencing. This work will include patients with breast, colorectal, endometrial, haematological, lung, ovarian and renal cancers, as well as childhood cancers (e.g. sarcoma). These cancers were selected as this project is an extension of the Genomics England research project RR668 (Evaluating healthcare resource use and costs for cancer patients undergoing genome sequencing).

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