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Detection and clinical characterisation of virally-derived structural variants in head and neck cancer
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Cancer arises in large part through changes in the DNA of normal cells. These changes in the DNA can affect how the cell grows and multiplies, potentially leading it to eventually grow into a cancer. The term ‘structural variant’ is used to describe changes where the DNA is rearranged, such when two pieces of DNA become joined in a way that is abnormal. These structural variants (or ‘SV’s) can lead to growth advantages for cancer cells, but little is known about their impact in Head and Neck cancer. Many Head and Neck (HNN) cancers have been linked to infection with the Human Papilloma Virus (HPV), and these viruses can merge with host DNA, appearing like structural variants. Our goal is to study whether the sites of virus insertion are producing mutations that could be causing cancer, and whether we can characterise and sub-divide these tumours on this basis. This could be important for not only understanding how HNN can develop initially, but also for offering new drug targets and ways to screen patients.
